. 2017 Aug 3;38(11):1554–1565. doi: 10.1038/aps.2017.54

Table 2. Pharmacokinetic parameters of zidovudine (AZT) after oral administration of 20 mg/kg AZT or intravenous administration of 10 mg/kg AZT to acute liver failure (ALF) rats and age-matched control (CON) rats. Data are expressed as mean±SD. n=6. ^*P<0.05, ^**P<0.01 vs CON rats.

Group	CON	ALF
Oral administration
k (1/h)	0.65±0.08	0.37±0.04^**
t_1/2 (h)	1.07±0.15	1.91±0.22^**
T_max (h)	0.71±0.10	0.54±0.10^*
C_max (μg/mL)	5.72±0.70	7.76±0.88^**
AUC_0-t (μg·h·mL⁻¹)	10.74±1.28	16.14±2.52^**
AUC_0-∞ (μg·h·mL⁻¹)	10.82±1.29	16.53±2.52^**
V_z/F (L/kg)	2.89±0.44	3.43±0.89
CL/F (L·h⁻¹)	1.87±0.23	1.23±0.19^**
MRT (h)	1.83±0.19	2.55±0.11^**
Intravenous administration
k (1/h)	1.57±0.13	0.88±0.13^**
t_1/2 (h)	0.44±0.04	0.80±0.13^**
C₀ (μg/mL)	14.15±2.52	17.74±3.83^**
AUC_0-t (μg·h·mL⁻¹)	8.09±1.42	12.39±1.28^**
AUC_0-∞ (μg·h·mL⁻¹)	8.17±1.43	12.57±1.34^**
V_z (L/kg)	0.76±0.16	0.75±0.06
CL (L·h⁻¹)	1.25±0.20	0.80±0.08^**
MRT (h)	0.61±0.07	0.94±0.08^**

Table 2. Pharmacokinetic parameters of zidovudine (AZT) after oral administration of 20 mg/kg AZT or intravenous administration of 10 mg/kg AZT to acute liver failure (ALF) rats and age-matched control (CON) rats. Data are expressed as mean±SD. n=6. *P<0.05, **P<0.01 vs CON rats.