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Artist's view of the Hsp70/Hsp40 chaperone network of the human ER. See text for details. The following binding characteristics (KD) were observed for BiP binding in the presence of ATP (in μM): ERj1, 0.12; Sec63, 5; ERj3, 3.5; ERj4, 6.07; ERj5, 0.45; ERj6, 0.59; ERj7, 1.1. The cartoon and affinities are based on Schorr et al. (2015).
