Table 2.
Relative abundance of prevalent bacterial groups in response to treatments in the healthy group†
| Placebo | Livaux™ | ACTAZIN™ L | ACTAZIN™ H | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pre | Post | Pre | Post | Pre | Post | Pre | Post | |||||||||
| Mean | sem | Mean | sem | Mean | sem | Mean | sem | Mean | sem | Mean | sem | Mean | sem | Mean | sem | |
| Bacteroides | 18·8 | 4·0 | 18·0 | 3·2 | 23·1 | 4·6 | 22·0 | 4·2 | 16·7 | 3·1 | 18·4 | 3·9 | 19·4 | 3·2 | 18·1 | 3·8 |
| Ruminococcaceae‡ | 16·3 | 2·4 | 19·6 | 3·0 | 17·4 | 2·3 | 17·8 | 2·5 | 19·9 | 2·5 | 22·2 | 3·8 | 18·4 | 2·6 | 19·9 | 3·3 |
| Lachnospiraceae‡ | 10·8 | 1·3 | 11·0 | 1·5 | 11·9 | 1·9 | 9·5 | 1·3 | 11·6 | 1·6 | 9·3 | 1·7 | 11·6 | 1·6 | 11·0 | 1·4 |
| Faecalibacterium | 7·0 | 1·5 | 5·7 | 1·0 | 7·2 | 1·6 | 5·3 | 0·9 | 6·3 | 1·6 | 4·6 | 0·8 | 6·7 | 1·1 | 6·5 | 1·6 |
| Clostridiales‡ | 5·9 | 0·9 | 5·7 | 1·0 | 5·0 | 0·9 | 7·6* | 1·1 | 5·9 | 0·7 | 5·0 | 1·1 | 6·6 | 1·2 | 5·6 | 0·9 |
| Coprococcus | 6·6 | 1·0 | 5·5 | 0·8 | 5·9 | 1·1 | 5·1 | 0·7 | 5·4 | 0·8 | 5·2 | 0·8 | 5·1 | 0·8 | 4·9 | 0·8 |
| Blautia | 5·8 | 0·9 | 4·7 | 1·0 | 4·3 | 0·6 | 4·8 | 1·0 | 4·7 | 0·7 | 6·3 | 1·7 | 4·8 | 1·1 | 6·1 | 1·8 |
| Ruminococcus_R | 4·4 | 1·0 | 5·9 | 1·6 | 3·8 | 0·6 | 3·7 | 1·0 | 5·3 | 1·0 | 5·9 | 1·3 | 3·5 | 0·8 | 4·4 | 1·2 |
| Rikenellaceae‡ | 2·8 | 0·9 | 2·7 | 0·7 | 2·7 | 0·7 | 2·9 | 1·0 | 2·8 | 1·0 | 2·5 | 0·9 | 3·0 | 0·6 | 3·5 | 0·8 |
| Bifidobacterium | 3·0 | 1·0 | 2·3 | 0·6 | 2·5 | 1·2 | 2·1 | 0·6 | 2·0 | 0·4 | 3·5 | 1·1 | 2·7 | 0·9 | 2·6 | 0·8 |
| Bacteroidales‡ | 2·2 | 1·0 | 2·2 | 0·8 | 2·0 | 0·9 | 1·9 | 0·8 | 1·3 | 0·4 | 1·2 | 0·3 | 2·6 | 1·1 | 1·7 | 0·6 |
| Lachnospira | 1·6 | 0·5 | 1·1 | 0·2 | 1·3 | 0·3 | 1·5 | 0·5 | 1·0 | 0·2 | 1·1 | 0·3 | 1·8 | 0·5 | 1·3 | 0·4 |
| Parabacteroides | 1·2 | 0·3 | 1·6 | 0·5 | 1·8 | 0·6 | 1·1 | 0·2 | 1·3 | 0·3 | 1·0 | 0·2 | 1·7 | 0·3 | 1·5 | 0·3 |
| Collinsella | 1·8 | 0·7 | 1·2 | 0·4 | 0·9 | 0·4 | 1·3 | 0·4 | 1·6 | 0·6 | 1·2 | 0·3 | 1·5 | 0·6 | 1·1 | 0·3 |
| Akkermansia | 1·3 | 0·5 | 1·4 | 0·6 | 1·8 | 0·7 | 1·6 | 0·7 | 1·6 | 0·6 | 1·8 | 0·5 | 1·4 | 0·4 | 1·0 | 0·3 |
| Oscillospira | 1·1 | 0·2 | 1·1 | 0·2 | 1·1 | 0·2 | 1·6 | 0·3 | 1·4 | 0·2 | 1·5 | 0·5 | 1·2 | 0·1 | 1·5 | 0·2 |
| Prevotella | 1·5 | 0·7 | 2·6 | 1·8 | 0·8 | 0·4 | 2·1 | 1·5 | 2·5 | 1·33 | 0·7 | 0·3 | 0·9 | 0·5 | 1·6 | 0·9 |
| Dorea | 1·2 | 0·4 | 1·2 | 0·3 | 0·9 | 0·2 | 1·5 | 0·4 | 1·1 | 0·2 | 0·9 | 0·2 | 0·8 | 0·2 | 1·0 | 0·2 |
| Clostridiaceae‡ | 1·5 | 0·4 | 0·9 | 0·3 | 0·9 | 0·2 | 0·9 | 0·2 | 0·8 | 0·2 | 1·2 | 0·4 | 0·8 | 0·2 | 0·9 | 0·3 |
| Unassigned | 0·8 | 0·1 | 1·0 | 0·2 | 0·8 | 0·1 | 1·0 | 0·2 | 0·9 | 0·1 | 0·9 | 0·1 | 0·8 | 0·1 | 0·8 | 0·1 |
L, low dose; H, high dose; Ruminococcus_R, from Ruminococcaceae family.
*
Significantly different compared with pre-treatment based on the Wilcoxon signed rank test after false discovery rate correction for multiple comparisons (P ≤ 0·05).
†
Illumina MiSeq sequencing data displaying genera that are present at greater than 1 % abundance in at least one sample. Data are the calculated average values for all participants with their standard errors before and after each treatment period.
‡ Some bacteria could only be classified as far as the order or family level.