Table 3.
Relative abundance of prevalent bacterial groups in response to treatments in the functionally constipated group†
| Placebo | Livaux™ | ACTAZIN™ L | ACTAZIN™ H | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pre | Post | Pre | Post | Pre | Post | Pre | Post | |||||||||
| Mean | sem | Mean | sem | Mean | sem | Mean | sem | Mean | sem | Mean | sem | Mean | sem | Mean | sem | |
| Ruminococcaceae‡ | 17·2 | 2·3 | 19·9 | 2·9 | 17·1 | 3·8 | 16·3 | 2·1 | 17·9 | 2·6 | 15·0 | 2·3 | 16·5 | 3·1 | 18·8 | 2·1 |
| Bacteroides | 12·6 | 3·1 | 14·4 | 2·2 | 14·2 | 2·6 | 15·5 | 2·6 | 13·9 | 2·2 | 12·2 | 2·5 | 14·0 | 2·9 | 16·3 | 3·1 |
| Lachnospiraceae‡ | 11·4 | 1·6 | 8·0 | 2·3 | 10·0 | 2·5 | 13·9 | 3·3 | 10·8 | 3·1 | 11·0 | 2·3 | 11·7 | 2·5 | 8·7 | 2·2 |
| Faecalibacterium | 7·9 | 2·8 | 5·8 | 2·1 | 3·4 | 1·0 | 7·0* | 1·1 | 4·9 | 1·7 | 5·0 | 1·4 | 7·7 | 2·1 | 3·1 | 1·0 |
| Clostridiales‡ | 4·8 | 0·6 | 6·8 | 1·7 | 6·4 | 1·3 | 5·5 | 1·1 | 6·4 | 1·2 | 6·7 | 1·7 | 6·0 | 1·4 | 7·5 | 1·8 |
| Coprococcus | 6·5 | 1·4 | 6·1 | 1·1 | 6·7 | 1·7 | 6·6 | 1·4 | 6·9 | 1·4 | 8·6 | 1·2 | 6·0 | 1·2 | 7·1 | 1·9 |
| Blautia | 6·6 | 1·8 | 3·5 | 0·9 | 7·1 | 2·0 | 6·0 | 1·5 | 6·9 | 1·5 | 7·5 | 1·8 | 5·9 | 2·1 | 5·4 | 1·3 |
| Ruminococcus_R | 9·4 | 2·6 | 5·1 | 1·0 | 5·7 | 1·4 | 4·9 | 0·7 | 5·5 | 2·0 | 6·7 | 1·5 | 5·1 | 1·1 | 6·6 | 1·3 |
| Bifidobacterium | 2·6 | 1·3 | 2·6 | 1·0 | 3·5 | 1·5 | 2·6 | 1·0 | 2·7 | 1·5 | 2·7 | 0·9 | 4·0 | 1·6 | 1·8 | 0·8 |
| Akkermansia | 2·7 | 1·7 | 4·8 | 2·0 | 5·0 | 1·8 | 2·6 | 1·0 | 3·3 | 1·1 | 3·3 | 1·5 | 3·6 | 1·0 | 5·6 | 2·3 |
| Rikenellaceae‡ | 2·3 | 0·6 | 3·1 | 0·6 | 3·9 | 1·2 | 2·4 | 0·5 | 4·0 | 1·1 | 3·9 | 1·3 | 2·6 | 0·7 | 3·2 | 0·9 |
| Christensenellaceae‡ | 1·0 | 0·6 | 1·5 | 0·6 | 2·2 | 1·4 | 1·1 | 0·6 | 1·8 | 0·8 | 1·4 | 0·6 | 2·3 | 1·6 | 2·2 | 1·3 |
| Prevotella | 1·8 | 1·1 | 0·6 | 0·3 | 0·2 | 0·1 | 0·5 | 0·3 | 0·5 | 0·3 | 0·9 | 0·5 | 2·0 | 1·1 | 0·2 | 0·1 |
| Collinsella | 1·6 | 0·6 | 1·2 | 0·3 | 1·6 | 0·4 | 1·3 | 0·3 | 1·2 | 0·4 | 1·8 | 0·7 | 1·6 | 0·6 | 1·4 | 0·3 |
| Parabacteroides | 1·3 | 0·4 | 1·3 | 0·4 | 1·2 | 0·3 | 1·3 | 0·4 | 1·7 | 0·4 | 1·2 | 0·4 | 1·3 | 0·4 | 1·5 | 0·3 |
| Oscillospira | 1·3 | 0·1 | 1·5 | 0·3 | 1·6 | 0·2 | 1·8 | 0·3 | 1·6 | 0·2 | 1·5 | 0·3 | 1·3 | 0·2 | 1·8 | 0·3 |
| Lachnospira | 1·0 | 0·5 | 1·0 | 0·4 | 0·6 | 0·2 | 1·6 | 0·9 | 1·3 | 0·5 | 1·2 | 0·5 | 1·3 | 0·6 | 0·5 | 0·1 |
| Dorea | 1·5 | 0·4 | 1·4 | 0·3 | 1·3 | 0·3 | 1·2 | 0·3 | 1·2 | 0·3 | 1·2 | 0·4 | 0·9 | 0·2 | 1·4* | 0·3 |
| Coriobacteriaceae‡ | 0·9 | 0·3 | 1·2 | 0·5 | 1·5 | 0·4 | 1·2 | 0·5 | 1·1 | 0·3 | 1·1 | 0·3 | 0·8 | 0·2 | 1·2 | 0·4 |
| Barnesiellaceae‡ | 0·9 | 0·3 | 4·0 | 2·4 | 1·0 | 0·4 | 1·0 | 0·3 | 1·1 | 0·3 | 1·4 | 0·5 | 0·8 | 0·3 | 0·8 | 0·3 |
| Clostridiaceae‡ | 0·4 | 0·1 | 1·5 | 0·7 | 0·9 | 0·5 | 1·0 | 0·7 | 0·3 | 0·1 | 0·4 | 0·1 | 0·4 | 0·1 | 0·3 | 0·1 |
| Unassigned | 1·0 | 0·1 | 1·1 | 0·1 | 1·1 | 0·2 | 1·0 | 0·1 | 1·0 | 0·1 | 1·0 | 0·1 | 1·3 | 0·4 | 1·0 | 0·1 |
L, low dose; H, high dose; Ruminococcus_R, from Ruminococcaceae family.
*
Significantly different compared with pre-treatment based on the Wilcoxon signed rank test after false discovery rate correction for multiple comparisons (P ≤ 0·05).
†
Illumina MiSeq sequencing data displaying genera that are present at greater than 1 % abundance in at least one sample. Data are the calculated average values for all participants with their standard errors before and after each treatment period.
‡ Some bacteria could only be classified as far as the order or family level.