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. Author manuscript; available in PMC: 2017 Nov 6.
Published in final edited form as: Biomark Med. 2014;8(10):1239–1245. doi: 10.2217/bmm.14.82

Figure 1. Shown is the relation between function and time in the setting of a set of hypothetical insults (A–C).

Figure 1

In the most straightforward scenario, insult A occurs in the setting of normal function (1) and following the insult function declines (2). Function may also recover (3) or there may be discernible change (4). Baseline function may already be impaired (line 5). Functional decline may also be due to an extrarenal process (e.g., shock) and only later does damage (B) occur. Finally, many patients may have multiple insults (A–C) occurring over time. Some may be ‘silent’ (C), others may occur after (B) the initial insult.