Table 2.
Predictors of IBS. The covariates in the analyses were the groups (neurological/depression), depression (BDI-II), and one by one of the other variables.
| Group | BDI-II | Other variables | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | |
| 2.93 (0.95; 9.03) | 0.062 | |||||
| 0.66 (0.13; 3.31) | 0.617 | 1.07 (1.02; 1.12) | 0.012 | |||
| 0.58 (0.11; 3.00) | 0.511 | 1.07 (1.02; 1.13) | 0.009 | Gender (male) | 1.71 (0.58;5.09) | 0.333 |
| 0.64 (0.13; 3.24) | 0.590 | 1.07 (1.02; 1.13) | 0.011 | Age (years) | 1.00 (0.97;1.05) | 0.723 |
| 0.69 (0.14; 3.46) | 0.651 | 1.07 (1.02; 1.13) | 0.009 | IL-10 serum (pg/ml) | 1.12 (0.88;1.43) | 0.357 |
| 0.75 (0.15; 3.79) | 0.725 | 1.07 (1.02; 1.12) | 0.013 | TNF serum (pg/ml) | 1.07 (0.95; 1.20) | 0.246 |
| 0.73 (0.14; 3.72) | 0.702 | 1.07 (1.02; 1.12) | 0.011 | TNF/IL-10 ratio serum | 0.97 (0.87; 1.08) | 0.572 |
| 0.59 (0.10; 3.46) | 0.561 | 1.07 (1.01; 1.13) | 0.020 | IL-10-CSF (pg/ml) | 0.15 (0.02; 0.97) | 0.047 |
| 0.56 (0.10; 3.11) | 0.509 | 1.08 (1.02; 1.13) | 0.008 | TNF-CSF (pg/ml) | 1.10 (0.57; 2.11) | 0.776 |
| 0.59 (0.11; 3.33) | 0.550 | 1.07 (1.02; 1.13) | 0.011 | TNF/IL-10 ratio CSF | 1.34 (0.52; 3.48) | 0.548 |
| 0.49 (0.09; 2.76) | 0.418 | 1.08 (1.02; 1.14) | 0.007 | Kynurenine serum | 1.52 (0.54; 4.30) | 0.429 |
| 0.46 (0.08; 2.61) | 0.384 | 1.08 (1.02; 1.15) | 0.005 | Tryptophan serum | 1.05 (0.99; 1.11) | 0.107 |
| 0.56 (0.10; 3.05) | 0.500 | 1.08 (1.02; 1.14) | 0.008 | K/T × 1000 serum | 0.99 (0.94; 1.05) | 0.754 |
| 0.55 (0.10; 2.97) | 0.482 | 1.08 (1.02; 1.14) | 0.008 | Kynurenine CSF | >1.00 | 0.019 ∗ |
| 0.53 (0.09; 3.19) | 0.489 | 1.08 (1.02; 1.14) | 0.009 | Tryptophan CSF | >1.00 | 0.048 ∗ |
| 0.54 (0.10; 2.96) | 0.480 | 1.08 (1.02; 1.14) | 0.008 | K/T × 1000 CSF | 1.00 (0.95; 1.05) | 0.844 |
| 0.32 (0.04; 2.29) | 0.254 | 1.13 (1.04; 1.22) | 0.004 | Propionic acid faeces | 1.90 (1.04; 3.46) | 0.036 |
| 0.35 (0.05; 2.34) | 0.280 | 1.11 (1.03; 1.20) | 0.007 | Butyric acid faeces | 1.06 (0.67; 1.69) | 0.800 |
| 0.08 (0.01; 1.10) | 0.059 | 1.17 (1.05; 1.31) | 0.006 | PmB faeces | 6992 (10; 4,793,010) | 0.008 |
∗Fractional polynomial logistic regression. BDI-II: Beck Depression Inventory-II; IL-10 serum: interleukin 10 in the serum; TNF serum: tumor necrosis factor in serum; IL-10-CSF: interleukin 10 in the cerebrospinal fluid; TNF-CSF: tumor necrosis factor in the cerebrospinal fluid; PmB: propionic acid minus butyric acid in faeces; K/T ratio × 1000: kynurenine/tryptophan ratio × 1000.