Table 3.
Predictors of IBS-SSS. The covariates in the analyses were the groups (neurological/depression), depression (BDI-II), and one by one of the other variables.
| Group | BDI-II | Other variables | ||||
|---|---|---|---|---|---|---|
| B (95% CI) | p value | B (95% CI) | p value | B (95% CI) | p value | |
| 86 (31; 141) | 0.003 | |||||
| 28 (−45; 102) | 0.444 | 2.4 (0.3; 4.6) | 0.027 | |||
| 23 (−51; 98) | 0.533 | 2.6 (0.4; 4.7) | 0.021 | Gender (male) | 24 (−24; 73) | 0.317 |
| 23 (−51; 98) | 0.529 | 2.8 (0.6; 5.0) | 0.015 | Age (years) | 1.0 (−0.7; 2.8) | 0.252 |
| 28 (−46; 102) | 0.454 | 2.4 (0.2; 4.6) | 0.031 | IL-10 serum (pg/ml) | −1.5 (−12.6; 9.6) | 0.787 |
| 30 (−45; 105) | 0.429 | 2.4 (0.3; 4.6) | 0.029 | TNF serum (pg/ml) | 0.8 (−3.9; 5.4) | 0.745 |
| 24 (−51; 99) | 0.526 | 2.4 (0.3; 4.6) | 0.028 | TNF/IL-10 ratio serum | 1.8 (−3.2; 6.8) | 0.480 |
| 23 (−54; 99) | 0.551 | 2.3 (0.0; 4.5) | 0.048 | IL-10-CSF (pg/ml) | −69 (−146; 9) | 0.084 |
| 30 (−46; 106) | 0.432 | 2.5 (0.3; 4.7) | 0.024 | TNF-CSF (pg/ml) | 32 (3; 61) | 0.030 |
| 33 (−42; 108) | 0.380 | 2.2 (0.0; 4.4) | 0.046 | TNF/IL-10 ratio CSF | 55 (13; 97) | 0.012 |
| 21 (−58; 101) | 0.595 | 2.7 (0.5; 2.0) | 0.020 | Kynurenine serum | 0.5 (−46.2; 47.1) | 0.984 |
| 24 (−53; 102) | 0.530 | 2.6 (0.4; 4.9) | 0.021 | Tryptophan serum | −1.4 (−3.5; 0.7) | 0.194 |
| 17 (−61; 95) | 0.668 | 2.8 (0.5; 5.0) | 0.017 | K/T × 1000 serum | 1.3 (−1.2; 3.8) | 0.304 |
| 34 (−44; 111) | 0.387 | 2.4 (0.2; 4.6) | 0.034 | Kynurenine CSF (pg/ml) | >1 | 0.062∗ |
| 22 (−56; 100) | 0.577 | 2.8 (0.6; 5.0) | 0.015 | Tryptophan CSF (pg/ml) | >1 | 0.150∗ |
| 21 (−57; 99) | 0.589 | 2.7 (0.5; 5.0) | 0.019 | K/T × 1000 CSF | −0.3 (−2.6; 2.0) | 0.797 |
| 40 (−42; 122) | 0.332 | 2.6 (−0.2; 5.3) | 0.065 | Propionic acid faeces (mmol/l) | 1.9 (−20.7; 24.4) | 0.869 |
| 35 (−47; 118) | 0.390 | 2.5 (−0.2; 5.2) | 0.070 | Butyric acid faeces (mmol/l) | −7.2 (−27.7; 13.2) | 0.481 |
| 22 (−58; 102) | 0.580 | 2.4 (−0.1; 5.1) | 0.063 | PmB faeces (mmol/l) | 44 (−0.4; 87.6) | 0.052 |
∗Fractional polynomial linear regression. BDI-II: Beck Depression Inventory-II; IL-10 serum: interleukin 10 in the serum; TNF serum: tumor necrosis factor in serum; IL-10-CSF: interleukin 10 in the cerebrospinal fluid; TNF-CSF: tumor necrosis factor in the cerebrospinal fluid; PmB: propionic acid minus butyric acid in faeces; K/T ratio × 1000: kynurenine/tryptophan ratio × 1000.