Table 2.

Multinomial Analysis of Phenotype Predictors

	Rising TSH/falling fT4	Rising TSH/rising fT4	Falling TSH/falling fT4	Falling TSH/rising fT4
Initial age (years)
60–69	3.1 [0.6–15.5]	1.6 [0.5–5.8]	0.4 [0.1–1.6]	2.9 [0.8–11]
70–79	7.7 [1.6–35]#	1.2 [0.3–5.2]	1.1 [0.3–3.7]	4.0 [1.0–15.2]*
80+	8.5 [1.6–43]*	4.9 [1.2–19.7]*	1.9 [0.6–6.4]	6.6 [1.6–26.6]#
Male	1.2 [0.5–2.6]	1.0 [0.4–2.4]	0.8 [0.3–1.8]	0.6 [0.3–1.3]
White	1.1 [0.4–2.8]	0.4 [0.2–1.1]	0.7 [0.3–1.9]	0.8 [0.3–1.9]
Smoker	1.0 [1.3–8.3]	2.5 [0.5–11.9]	7.2 [1.9–27.4]#	2.1 [0.4–9.7]
Baseline TSH (mIU/L)	1.1 [0.8–1.5]	1.1 [0.8–1.6]	2.0 [1.5–2.6]**	1.4 [1.1–1.7]*
Baseline fT4 (0.1 ng/dL)	1.1 [0.9–1.5]	0.7 [0.5–1.0]	1.9 [1.4–2.5]**	0.7 [0.5–0.9]*

Hazard ratio and confidence intervals for each risk factor by phenotype. Statistically significant values are shown in bold.

^*p < 0.05; ^#p < 0.01; ^**p < 0.001.