Table 3.
Multivariable Analysis of the Association of Treatment and Prognostic Variables With Overall Survival
| No. of Patients |
No. of Deaths |
Adjusted HR (95% CI)a | P Value | |
|---|---|---|---|---|
| Lymph node dissection group | ||||
| Sentinel alone | 426 | 51 | 0.93 (0.64–1.36) | .72 |
| Axillary | 413 | 56 | 1 [Reference] | |
| Age group, y | ||||
| ≤50 | 295 | 23 | 1 [Reference] | .002 |
| >50 | 544 | 84 | 2.08 (1.31–3.30) | |
| Estrogen receptor and progesterone receptor status | ||||
| Both negative | 101 | 25 | 1 [Reference] | .02 |
| ≥1 Positive | 514 | 61 | 0.57 (0.36–0.91) | |
| Lymphovascular invasion | ||||
| Absent | 238 | 31 | 1 [Reference] | .74 |
| Present | 387 | 48 | 0.92 (0.59–1.46) | |
| Sentinel lymph node met size | ||||
| Micrometastases (≤2 mm) | 296 | 37 | 1 [Reference] | .97 |
| Macrometastases (>2 mm) | 418 | 53 | 1.01 (0.66–1.54) | |
| Pathological tumor size, cm (continuous) | 1.19 (1.07–1.32) | .001 | ||
| Histological type | ||||
| Ductal | 687 | 86 | 1 [Reference] | .25 |
| Lobular | 63 | 9 | 1.04 (0.52–2.07) | |
| Mixed ductal and lobular | 32 | 8 | 2.06 (0.99–4.27) | |
| Other | 41 | 4 | 0.79 (0.29–2.16) | |
| Gradeb | ||||
| 1 | 150 | 20 | 1 [Reference] | .46 |
| 2 | 300 | 31 | 0.74 (0.42–1.30) | |
| 3 | 178 | 26 | 1.07 (0.60–1.92) | |
| Unknown or missing | 144 | 21 | 1.06 (0.58–1.96) |
Abbreviation: HR, hazard ratio.
a
Model includes study group, age, and adjuvant therapy.
b
Defined using the modified Bloom-Richardson system. Patients with lower grades have a better prognosis.