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. Author manuscript; available in PMC: 2017 Nov 6.
Published in final edited form as: Lancet Respir Med. 2016 Jun 10;4(8):636–645. doi: 10.1016/S2213-2600(16)30105-9

Table 2.

Unadjusted and adjusted linear regression models for the association between clinical factors and the PA:A Ratio

A. Derivation cohort
PA:A Ratio
Unadjusted Adjusteda
Beta P-value Beta P-value
Age, years −0.32 0.005 −0.34 0.007
BMI, kg/m2 −0.08 0.46
Sweat chloride, mmol/L 0.25 0.05 0.21 0.08
FEV1% predicted 0.04 0.76
FEV1/FVC 0.14 0.22
B. Validation cohort
PA:A Ratio
Unadjusted Adjustedb Adjustedc
Beta P-value Beta P-value Beta P-value
Age, years −0.28 <0.001
BMI, kg/m2 −0.15 0.05
Sweat chloride, mmol/L 0.37 0.05 0.32 0.11 0.36 0.06
FEV1% predicted −0.04 0.63
FEV1/FVC 0.07 0.33
a

Model adjusted for age, sweat chloride, FEV1% predicted. The R2 for the adjusted model is 0.17 (P=0.004). Abbreviations: BMI = body mass index, FEV1 = forced expiratory volume in 1 second, FVC = forced vital capacity.

b

Model adjusted for age, sweat chloride, FEV1% predicted with R2 = 0.17 (P=0.10).

c

Model adjusted for age, sweat chloride, BMI with R2 = 0.13 (P=0.07).

Abbreviations: BMI = body mass index, FEV1 = forced expiratory volume in 1 second, FVC = forced vital capacity.