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. 2017 Sep 12;117(9):1371–1382. doi: 10.1038/bjc.2017.297

Figure 4.

Figure 4

Increased Ang2 enhanced the IGF1 secretion of TEMs and TEK-U937. (A and B) Ang2 stimulation increased the IGF1 expression in TEK-U937 (n=3) and primary TEMs (n=3, student’s t-test). (C) IGF1 level was significantly increased in ascites of EOC patients (n=14) compared with the serum of EOC patients (n=17) and benign ovarian cysts patients (n=20, student’s t-test) according to the ELISA assay. (D) IGF1 level in ovarian tissues of EOC patients (n=124) and benign ovarian cysts patients (n=75) was detected by immunohistochemistry. (E) The IGF1 expression is significantly higher in EOC ovarian tissues compared with benign ovarian cysts patients (student’s t-test).