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. 2017 Sep 12;117(9):1371–1382. doi: 10.1038/bjc.2017.297

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Copyright © 2017 The Author(s)

This work is licensed under the Creative Commons Attribution-Non-Commercial-Share Alike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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TEK-U937-promoted tumour development and metastasis in vivo. (A) SKOV3-Luc expression was detected by BLI in the tumour burden mouse model. (B and C) The TEK-U937 group showed significantly higher flux and tumour weight compared with the NC-U937 and control groups (n=6 in each group, Mann–Whitney test). (D) TEK-U937 significantly promoted tumour metastasis compared to the NC-U937 and control groups (Pearson Chi-square test). (E–H) IGF1 blocking antibody reversed the increased tumour flux, tumour weight and tumour metastasis promoted by TEK-U937 (n=6).