Table 4. Immunohistochemical results on tumour and benign tissue in biopsy and surgical specimens.
|
Tumour
tissue |
||||
|---|---|---|---|---|
|
Wait-list control |
Weight loss intervention |
|||
| Biopsy (n=9) | Surgery (n=16) | Biopsy (n=14) | Surgery (n=18) | |
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | |
| Androgen receptor | 0.8 (0.6, 1.6) | 1.7 (1.0, 2.0) | 1.5 (0.1, 2.7) | 1.8 (0.8, 2.85) |
| Insulin receptor | 2.0 (1.4, 2.0) | 1.0 (1.0, 2.0) | 2.0 (2.0, 3.0) | 1.9 (1.0, 2.0) |
| NF-κB p65 | 1.7 (1.1, 1.9) | 1.0 (0.95, 1.8) | 1.9 (1.0, 2.0) | 1.2 (1.0, 1.9) |
| 4E-BP1 | 0.45 (0.13, 1.10) | 0.85 (0.45, 1.2) | 0.6 (0.1, 1.2) | 1.3 (0.6, 1.7) |
| Ki67 (%) | 2.5 (2.5,10.0) | 0.0 (0.0, 2.5) | 2.25 (0.0, 5.0) | 5.0 (2.5, 10.0)a |
| Benign tissue | ||||
| Wait-list control | Weight loss intervention | |||
| Biopsy (n=13) | Surgery (n=16) | Biopsy (n=17) | Surgery (n=18) | |
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | |
| Androgen receptor | 0.6 (0.2, 1.2) | 1.6 (0.5, 1.8) | 0.8 (0.4, 1.8) | 1.7 (1.0, 2.25) |
| Insulin receptor | 2.0 (2.0, 2.0) | 2.0 (1.7, 2.0) | 2.0 (2.0, 2.0) | 2.0 (1.8, 2.0) |
| NF-κB p65 | 2.0 (0.4, 1.8) | 1.6 (0.95, 2.0) | 2.0 (2.0, 2.0) | 1.6 (0.9, 1.8) |
| 4E-BP1 | 0.0 (0.0, 0.05) | 0.15 (0.08, 0.3) | 0.0 (0.0. 0.05) | 0.1 (0.1, 0.2) |
| Ki67 (%) | 0.0 (0.0, 0.0) | 0.0 (0.0, 3.75) | 0.0 (0.0, 2.5) | 2.5 (0.0, 5.0) |
Abbreviations: IQR=interquartile range; NF-κB=nuclear factor-κB.
a
Ki67 (%) difference between group at surgery Wilcoxon’s rank-sum test P=0.0061.