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. 2017 Sep 5;117(9):1336–1340. doi: 10.1038/bjc.2017.307

Figure 3.

Figure 3

Decreasing Ffar2 expression increases leukaemic cell accumulation in vivo. Ffar2 expression in BaF cells in vitro (five independent experiments performed in triplicate) (A). Number of intact BaF cells per ml 48 h after incubation (four independent experiments) (B). White blood cell count (C). Bcr-Abl expression in spleen (D), lungs (E), subcutaneous adipose tissue (F) and liver (G). Ffar2 expression in liver (H). For C–H, CT: control mice (n=4), BaF-shCT: mice transplanted with BaF cells transduced with a control shRNA (n=8), BaF-shFFAR2: mice transplanted with BaF cells transduced with a shRNA targeting FFAR2 (n=9). *P<0.05, **P<0.01, ***P<0.001 vs BaF-shCT. Paired t-test for B.