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. 2017 Oct 31;12:8025–8034. doi: 10.2147/IJN.S146875

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© 2017 Wu et al. This work is published and licensed by Dove Medical Press Limited

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(A) Representative images of peripheral blood smears from T-ALL xenograft mice after treatment with IRAK/ABT-NP, IRAK1/4 inhibitor alone, ABT-737 alone and combined solution. (B) Changes of WBC in T-ALL xenograft mice after treatment with drugs in different formulations. (C) Survival curves in each treated group of mice.

Abbreviations: T-ALL, T cell acute lymphoblastic leukemia; IRAK/ABT-NP, IRAK1/4 inhibitor and ABT-737 co-encapsulated into polyethylene glycol modified poly (lactic-co-glycolic acid) nanoparticles; WBC, white blood cells.