Fig. 3.

Incidence of remission in BD-I mania, stratified by baseline AIA/depressive symptoms. ^# p-value significant (when adjusted for multiplicity), Chi squared test. Anxiety was defined as a PANSS anxiety item score of ≥3 at baseline. Irritability was defined as a YMRS irritability item score of ≥4 at baseline. Agitation was defined as a YMRS increased motor activity–energy item score of ≥3 at baseline. Severe AIA was defined as meeting the above criteria for all three AIA symptoms. Patients missing a value for the corresponding symptom at baseline were not included in the analysis. Two definitions were used for remission: a YMRS Total score of <12 at Day 21 (upper figures); and a YMRS Total score of <8 at Day 21 (lower figures) (observed cases). Depressive symptoms were defined in two ways: ≥3 individual MADRS items with a score of ≥1, or a MADRS Total score of ≥20 at baseline. AIA, anxiety, irritability, and agitation; BD-I, bipolar I disorder; MADRS, Montgomery–Åsberg Depression Rating Scale; PANSS, Positive and Negative Syndrome Scale; YMRS, Young Mania Rating Scale. a Presence or absence of baseline AIA symptoms and b presence or absence of baseline depressive symptoms