. Author manuscript; available in PMC: 2017 Nov 6.

Published in final edited form as: J Psychopharmacol. 2013 Sep 17;28(4):376–386. doi: 10.1177/0269881113504016

Table 1.

Effects of repeated aripiprazole treatment on D2 receptor densities in the dorsal striatum of adult rats

Author and year of publication	Rat strain	Dose and Route of administration	Duration	Effects
Inoue et al., 1997	Wistar	12 or 100 mg/kg/day, oral	21 days	Nonsignificant D2 receptor up-regulation
Seeman, 2008	Sprague-Dawley	1.5 mg/kg/day, subcutaneous	7 days	No D2 receptor up-regulation Increased percentage of D2^High receptors
Tadokoro et al., 2012	Sprague-Dawley	1.5 mg/kg/day, minipump	14 days	No D2 receptor up-regulation No DA supersensitivity