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Characteristics of the erythrocyte storage lesion.
| Biochemical | Structural |
|---|---|
| ↓TP | ↓membrane domain |
| ↓2,3 diphosphoglycerate | ↓deformability |
| ↓pH | ↑microparticles |
| ↓nitric oxide | ↑spherocytosis |
| ↑potassium | ↑hemolysis |
| ↑free hemoglobin | ↑band 3 oligomers |
| ↑lactate | ↑ceramide rafts |
| ↑cytokines | ↑external phospatidylserine |
| ↑reactive oxygen species | ↑aggregability |
| ↑soluble lipids | ↑osmotic fragility |
| ↑complement proteins | ↑protein cross-linking |
