Table II.

Incidence rates (95% CI) and hazard ratios (95% CI) of atrial fibrillation in association with galectin-3 percentiles, ARIC, 1996 – 2013.

	Galectin-3 (ng/ml)						P for trend
	0% – <25% (4.4 – 11.9)	25% – <50% (12.0 – 14.1)	50% – <75% (14.2 – 16.6)	75% – <90% (16.7 – 19.4)	90% – <95% (19.5 – 21.3)	95% – 100% (21.4 – 114.0)
N	2126	2130	2049	1283	411	437	-
Events, n	264	289	253	196	80	103	-
Person-years	30522	30466	29321	17604	5426	5219	-
Incidence rate*	8.6 (7.7 – 9.8)	9.5 (8.4 – 10.6)	8.6 (7.6 – 9.8)	11.1 (9.7 – 12.8)	14.7 (11.8 – 18.4)	19.7 (16.3 – 23.9)	-
Model 1	1 (Referent)	1.09 (0.92 – 1.28)	1.01 (0.85 – 1.20)	1.30 (1.07 – 1.57)	1.75 (1.35 – 2.26)	2.35 (1.86 – 2.99)	<0.0001
Model 2	1 (Referent)	1.06 (0.89 – 1.25)	0.92 (0.77 – 1.10)	1.11 (0.92 – 1.36)	1.37 (1.05 – 1.78)	1.67 (1.29 – 2.16)	0.0004
Model 3	1 (Referent)	1.15 (0.96 – 1.38)	1.05 (0.86 – 1.29)	1.30 (1.03 – 1.64)	1.63 (1.21 – 2.20)	2.02 (1.49 – 2.73)	<0.0001
Model 4	1 (Referent)	1.07 (0.90 – 1.28)	0.96 (0.78 – 1.17)	1.16 (0.92 – 1.46)	1.40 (1.04 – 1.89)	1.50 (1.10 – 2.05)	0.004

^*Incidence rate is unadjusted and per 1000 person-years.

Model 1: adjusted for age (continuous), race (white, black) and sex (female, male).

Model 2: Model 1 plus systolic blood pressure (continuous), blood pressure medications (yes, no), BMI (continuous), height (continuous), diabetes status (yes, no), total cholesterol (continuous), smoking status (current, former, never) and eGFR (continuous).

Model 3: Model 2 plus SNP rs4644 (CC, AC, AA).

Model 4: Model 3 plus ln NT-proBNP (continuous), ln CRP (continuous), and ln TnT (continuous).