Table 3. Autophagy markers in villous trophoblast.
| Characteristics | Groups | p-value | ||||
|---|---|---|---|---|---|---|
| Normal | Late PE | Early PE | IUGR | Total | ||
| (n = 10) | (n = 11) | (n = 9) | (n = 10) | (n = 40) | ||
| LC3B | ||||||
| Stained trophoblast (range) | 0.88 a (0.76; 0.94) |
0.78 (0.60; 0.93) |
0.92 (0.86; 0.96) |
0.97 a (0.90; 0.99) |
0.91 (0.60; 0.99) |
< 0.001$ |
| Relation strong vs weak/no staining (range) | 1.20 b (0.12; 4.05) |
0.35 b (0.08; 1.29) |
0.97 (0.39; 4.30) |
2.16 (0.50; 7.56) |
0.97 (0.08; 7.56) |
0.001$ |
| Beclin-1 | ||||||
| Stained trophoblast (SD) | 0.56 c,
d (0.12) |
0.55 (0.10) |
0.84 c (0.12) |
0.73 d (0.17) |
0.66 (0.17) |
< 0.001# |
| Relation strong vs weak/no staining (range) | 1.04 (0.06; 5.86) |
1.18 (0.29; 3.18) |
3.58 (0.02; 14.61) |
3.80 (0.03; 20.36) |
1.80 (0.02; 20.36) |
0.226$ |
Data is presented as mean (standard deviation) or median (min; max);
#One-way ANOVA Test;
$Kruskal-Wallis Test;
a: Post hoc test between normal pregnancy and IUGR (p = 0.002);
b: Post hoc test between normal pregnancy and late PE (p = 0.026);
c: Post hoc test between normal pregnancy and early PE (p<0.001);
d: Post hoc test between normal pregnancy and IUGR (p = 0.013).
When data showed normal distribution, mean and SD are shown. When data were not normally distributed, median and range are shown.