Table 2. Unadjusted and adjusted odds ratios for overall mortality in patients with acute symptomatic pulmonary embolism.

Risk factor	Unadjusted OR (95% CI)	P value	Adjusted OR (95% CI)	P value
Age, per year	1.02 (1.01–1.04)	< 0.001	1.02 (1.00–1.03)	0.08
Male gender	0.86 (0.61–1.21)	0.38	1.00 (0.63–1.57)	0.99
COPD	1.64 (0.96–2.80)	0.07	-	-
Congestive heart failure	2.39 (1.37–4.18)	< 0.01	3.52 (1.69–7.34)	< 0.01
Recent major bleeding†	3.06 (1.60–5.84)	< 0.01	4.10 (1.77–9.51)	< 0.01
Presence of DVT	1.78 (1.19–2.69)	< 0.01	1.69 (1.04–2.77)	0.04
SBP < 90 mmHg	3.79 (2.09–6.87)	< 0.001	3.30 (1.27–8.60)	0.01
Heart rate ≥ 110 bpm	1.51 (1.02–2.22)	0.04	1.13 (0.65–1.98)	0.66
Arterial oxyhemoglobin saturation < 90%	1.97 (1.38–2.80)	< 0.001	1.64 (1.01–2.68)	0.05
Dyspnea	1.83 (1.17–2.85)	< 0.01	0.98 (0.55–1.75)	0.95
Chest pain	0.51 (0.35–0.74)	< 0.001	0.68 (0.41–1.12)	0.13
Syncope	0.49 (0.26–0.92)	0.03	0.35 (0.15–0.86)	0.02
Cancer‡	3.63 (2.56–5.16)	< 0.001	5.35 (3.31–8.66)	< 0.001
Immobilizationy	1.51 (1.10–2.06)	0.01	1.63 (0.94–2.82)	0.08
Insertion of an IVC filter	1.61 (0.63–4.12)	0.32	-	-

Abbreviations: OR, odds ratio; CI, confidence interval; COPD, chronic obstructive pulmonary disease; DVT, deep vein thrombosis; SBP, systolic blood pressure; IVC, inferior vena cava.

^†In the previous month.

^‡Active or under treatment in the last year.

^yImmobilized patients are defined in this analysis as non-surgical patients who had been immobilized (i.e., total bed rest with bathroom privileges) for ≥4 days in the month prior to PE diagnosis.

N = 2,096 evaluated, with 62 deaths. Final model chi square = 31.81, P < 0.001