Table 3. Risk factors for disease relapse in HDG.
| Univariate analyses | Multivariate analyses | |||||||
|---|---|---|---|---|---|---|---|---|
| Remission (N = 210) |
Relapse (N = 90) |
OR | 95% CI | p value | OR | 95% CI | p value | |
| Age, years; mean | 48.2 | 45.5 | - | -0.79–6.10 | 0.13 | |||
| Age at onset, years; mean | 33.1 | 31.8 | - | -1.73–4.48 | 0.38 | |||
| Duration of disease, years; mean | 15.1 | 13.7 | - | -0.85–3.69 | 0.22 | |||
| Duration of disease remission, years; mean | 3.8 | 1.9 | - | 0.96–2.82 | <0.001 | 1.17 | 1.04–1.33 | <0.001 |
| serum Alb, g/dl; mean | 4.3 | 4.3 | - | -0.66–0.119 | 0.57 | |||
| TC level, mg/dl; mean | 198 | 190 | - | -2.10–16.5 | 0.13 | |||
| WBC counts, 103/μl; mean | 5.8 | 6.0 | - | -0.71–0.24 | 0.33 | |||
| Hb, g/dl; mean | 13.5 | 13.4 | - | -0.45–0.52 | 0.87 | |||
| Plt level, 104/μl; mean | 263 | 265 | - | -20.9–16.0 | 0.79 | |||
| CRP level, mg/dl; mean | 0.20 | 0.16 | - | -0.15–0.23 | 067 | |||
| ESR level, mm/h; mean | 9.0 | 11.1 | - | -6.04–1.69 | 0.27 | |||
| Mayo endoscopic score; mean | 0.71 | 1.00 | - | -0.56–0.017 | 0.041 | 1.62 | 1.005–2.62 | 0.047 |
| Male, n | 115 | 48 | 1.05 | 0.65–1.73 | 0.82 | |||
| Female, n | 95 | 42 | ||||||
| Previous steroid use (+), n | 57 | 32 | 1.48 | 0.87–2.51 | 0.14 | |||
| Previous steroid use (-), n | 153 | 58 | ||||||
| Previous thiopurine use (+), n | 11 | 6 | 1.06 | 0.36–3.16 | 0.91 | |||
| Previous thiopurine use (-), n | 169 | 70 | ||||||
n, number; SD, standard deviation; HDG, high dose group; LDG, low dose group; Alb, serum albumin; TC, total cholesterol; WBC, white blood cell count; Hb, haemoglobin; Plt, platelet; CRP serum C-reactive protein; ESR, erythrocyte sedimentation rate.