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. 2017 Nov 6;12(11):e0187565. doi: 10.1371/journal.pone.0187565

Fig 3. IDR-1002 reduced LPS-induced inflammatory cytokines and chemokine MCP-1 when added before or after the addition of LPS.

Fig 3

IDR-1002 at 12.5, 25, or 50 μM was added 24 or 4 h prior to P. aeruginosa LPS, at the same time as LPS (0 h), or 2 hours after LPS. Supernatants were collected 24 h after the addition of LPS for use in ELISAs for IL-6 (A), TNF-α (B), and MCP-1 (C). Data represent mean ± SEM from three independent experiments expressed as fold-change relative to LPS at each time point and were analyzed using two-way ANOVA and Dunnett’s multiple comparisons test. Only the significance for samples given LPS is displayed. **: p ≤ 0.01, ****: p ≤ 0.0001 compared to LPS.