Table 2. Summary of the statistical results for the three-way ANOVAs for the 6 genes of interest in the PFC, HPC, and HYPO.

Brain Region	Gene	Effect of Sex:F(p)	Effect of Injury: F(p)	Effect of Caffeine: F(p)	Significant Interactions
	Adora2a	0.02 (.89)	2.13 (.16)	5.01 (.03)	N/A
PFC	App	4.58 (.04)	2.05 (.16)	0.06 (.81)	Three-way interaction = 6.24 (.02)
	Aqp4	3.39 (.07)	0.88 (.36)	8.94 (< .01)	N/A
	Bdnf	6.47 (.02)	7.12 (.01)	0.31(.58)	N/A
	Gfap	0.21 (.66)	5.80 (.02)	22.55 (< .01)	Sex x Caffeine = 5.19 (.03)
					Injury x Caffeine = 4.56 (.04)
	Tau	3.12 (.09)	4.32 (.05)	1.77 (.19)	N/A
	Adora2a	17.96 (< .01)	3.21 (.08)	0.14 (.72)	Injury x Caffeine = 7.66 (.01)
					Three-way interaction = 6.94 (.01)
HPC	App	0.03 (.96)	1.23 (.28)	0.14 (.71)	N/A
	Aqp4	0.01 (.93)	0.77 (.39)	7.22 (.01)	N/A
	Bdnf	0.01 (.98)	4.15 (.05)	4.56 (.04)	Injury x Caffeine = 4.17 (.05)
	Gfap	0.63 (.44)	0.98 (.34)	4.14 (.06)	N/A
	Tau	9.87 (< .01)	1.52 (.23)	1.82 (.19)	Sex x Caffeine = 7.14 (.01)
HYPO	App	0.03 (.86)	0.73 (.41)	0.83 (.37)	Sex x Caffeine = 5.86 (.02)
	Bmal1	14.30 (< .01)	17.72 (< .01)	4.45 (.05)	Injury x Caffeine = 5.52 (.03)
	Clock	1.02 (.32)	7.55 (.01)	0.08 (.78)	Sex x Injury = 14.21 (< .01)
	Cry	0.39 (.54)	3.50 (.07)	0.37 (.55)	Three-way interaction = 4.28 (.05)
	Orx1	1.98 (.17)	0.11 (.75)	1.16 (.29)	N/A
	Orx2	0.07 (.80)	0.41 (.53)	8.97 (< .01)	Sex x Caffeine = 5.04 (.03)
					Sex x Injury = 5.01 (.03)
	Per	24.45 (< .01)	1.71 (.20)	0.01 (.95)	N/A
	Tau	6.92 (.01)	0.22 (.64)	0.19 (.67)	Sex x Caffeine = 4.22 (.05)