Table 1. Body weight and survival rate of immunized mice upon lethal challenge with influenza virus.
| Immunogen | Rate of body weight lossa) | Rate of body weight recoveryb) | Body weight loss, %c) | No. of survival (%)d) | Mean day of death, p.i.e) |
|---|---|---|---|---|---|
| PBS | -2.7±0.1 | - | 20.6±0.1 | 0/8 (0) | 7.0±0.5 |
| LL-HA1/L/AcmA | -0.3±0.1 | 0.3±0.1 | 11.6±2.5 ** | 7/8 (88) *** | 8.0±0.0 |
| HA1/L/AcmA | -0.6±0.1 | 0.3±0.1 | 15.7±1.8 * | 6/8 (75) ** | 7.0±0.0 |
| HA1/L/AcmA-FA | 0.2±0.0 | 0.2±0.0 | 1.5±0.7 *** | 8/8 (100) *** | >14.0 |
a), b) Rate of body weight loss and body weight recovery was calculated by linear regression analysis. Data are presented as mean ± standard deviation.
c) The maximum percentage change in body weight observed in individual mice over 14 days after lethal challenge with influenza virus. Data are presented as mean ± standard deviation.
d) Total number of mice survived following lethal challenge with influenza virus. Percentage of mice survived following virus challenge is presented in parentheses.
e) Day of death following lethal challenge with influenza virus. Data are presented as mean ± standard deviation.
Asterisks indicate statistically significant differences in comparison to the PBS-treated group (*p<0.05; **p<0.01; ***p<0.001).