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. 2017 Jul 28;102(11):4013–4022. doi: 10.1210/jc.2017-00562

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This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 1. — (a) The hematoxylin and eosin (H+E)-stained compact architecture and overall histological features consistent with a clear-cell RCC from proband 11 with a TMEM127 mutation. (b) Positive SDHB immunostaining in the same RCC tumor from proband 11. (c) Histological examination of a chromophobe RCC tumor from proband 3 with no detectable germline mutation (H+E staining ×200 high-power field). There is evidence of pleomorphic nuclei and perinuclear halos. (d) Positive SDHB immunostaining of the chromophobe RCC tumor.