Table 1.

Histomorphometric Results of Transiliac Bone Samples (Pretreatment)

Parameter	Patient 3 (15 y)	Controls (14-16.9 y) Mean (SD)	Patient 5 (10 y)	Controls (7–10.9 y) Mean (SD)
Structural parameters
Cortical width, μm	Not measurable	1178 ± 349	531	974 ± 367
Bone volume/tissue volume, %	37.0	25.7 ± 5.3	22.6	22.4 ± 4.2
Trabecular thickness, μm	163	157 ± 22	112	129 ± 17
Trabecular number, per mm	2.3	1.6 ± 0.2	2	1.7 ± 0.2
Static parameters of bone formation
Osteoid volume/bone volume, %	3.6	2.2 ± 0.9	3.4	2.6 ± 1.0
Osteoid thickness, μm	7.0	6.3 ± 1.0	8.4	5.9 ± 1.1
Osteoid surface/bone surface, %	43	26 ± 8	23	29 ± 13
Osteoblast surface/bone surface, %	25.3	7.9 ± 4.1	14.0	8.2 ± 4.4
Dynamic parameters of bone formation
Mineralizing surface/bone surface, %	30.9	12.5 ± 3.4	9.8	14.9 ± 4.5
Mineralizing apposition rate, μm/d	0.97	0.81 ± 0.09	1.05	0.95 ± 0.07
Adjusted apposition rate, µm/d	0.70	0.42 ± 0.11	0.44	0.47 ± 0.18
Bone formation rate/bone surface, μm/y	109	37 ± 10	38	52 ± 16
Bone formation rate/bone volume, %/y	133	48 ± 19	67	78 ± 27
Mineralization lag time, d	9.9	15.3 ± 3.6	18.9	14.1 ± 4.3
Static parameters of bone resorption
Eroded surface/bone surface, %	33	18 ± 6	30	17 ± 6
Osteoclast surface/bone surface, %	1.4	1.1 ± 0.7	1.7	1.3 ± 0.6
Number of osteoclasts/bone perimeter, per mm	0.6	0.3 ± 0.2	0.7	0.4 ± 0.2

Boldface indicates abnormal values.