Table 2.
HTN-IR Cohort Baseline Characteristics Defined by rs10144225 Genotype
| Major Allele Homozygotes (AA) (n = 553) | Carrier Allele Heterozygotes (AG) (n = 135) | Minor Allele Homozygotes (GG) (n = 4) | P Value | |
|---|---|---|---|---|
| Sex | ||||
| Females (%) | 324 (58.6) | 79 (58.5) | 3 (75) | 0.89 |
| Males (%) | 229 (41.4) | 56 (41.5) | 1 (25) | |
| Age, y | 37.8 ± 0.6 | 40.5 ± 1.2 | 31.5 ± 6.2 | 0.08 |
| Female (%) | ||||
| Age < 51 y (“premenopausal”) | 254 (78.4) | 55 (69.6) | 3 (100.0) | 0.08a |
| Age ≥ 51 y (“postmenopausal”) | 70 (21.6) | 24 (30.4) | 0 (0) | |
| Disease status (%) | ||||
| Hypertensive | 78 (14.1) | 36 (26.7) | 0 (0) | 0.002a |
| Normotensive | 475 (85.9) | 99 (73.3) | 4 (100.0) | |
| BMI, kg/m2 | 29.0 ± 0.2 | 29.1 ± 0.4 | 28.0 ± 2.8 | 0.90 |
| SBP, mm Hg | 120.6 ± 0.7 | 124.5 ± 1.8 | 112.9 ± 8.4 | 0.06 |
| DBP, mm Hg | 73.0 ± 0.4 | 75.2 ± 0.9 | 66 ± 1.5 | 0.03 |
Data are presented as mean ± SEM and P value reflects analysis of variance test unless otherwise indicated.
a
χ2 or Fisher’s exact test.