Table 3.

Association Between ESR2 rs10144225 and Outcomes in the HyperPATH Cohort

Regression Model	Univariate Analysis		Multivariate Analysis
	Coefficient Value (95% CI)	P Value	Coefficient value (95% CI)	P Value
ΔDBP on Lib–Resa	1.34 (0.14 to 2.55)	0.03	2.10 (0.83 to 3.37)	0.001
Estrogen replete	3.62 (0.48 to 6.77)	0.02	4.4 (1.46 to 7.33)	0.004
Estrogen deplete	1.53 (−0.33 to 3.40)	0.10	1.16 (−0.61 to 2.91)	0.20
PRA on Liba	−0.10 (−0.18 to −0.02)	0.01	−0.09 (−0.18 to 0)	0.04b
Estrogen replete	−0.09 (−0.22 to 0.023)	0.15	−0.03 (−0.21 to 0.12)	0.64
Estrogen deplete	−0.11 (−0.21 to −0.011)	0.03	−0.10 (−0.21 to −0.008)	0.05
ARR on Libc	6.28 (0.91 to 11.64)	0.02	6.74 (0.61 to 12.87)	0.031
Estrogen replete	12.96 (5.27 to 20.64)	0.001	15.03 (5.35 to 24.70)	0.003
Estrogen deplete	2.15 (−5.01 to 9.32)	0.55	1.62 (−6.23 to 9.48)	0.68

P values were obtained from linear regression analysis.

Abbreviations: Lib, liberal salt diet; Res, restricted salt diet.

^aAdjustment made for age, sex, BMI, race, and underlying disease.

^bThe statistical significance was lost after race was added in the model.

^cAdjustment made for age, sex, BMI, race, underlying disease, serum cortisol, serum potassium, and urine potassium level.