Table 2.
Top 10 Significant Canonical Pathways Identified in the Comparisons by Ingenuity Pathway Analysis Software
| Analysis | Pathway (Ingenuity Pathway Analysis) | Prediction State (z Score) | Genes Found/Database | P (Fisher Exact Test) | P (Benjamini–Hochberg Correction) |
|---|---|---|---|---|---|
| BTL vs NT | Reelin signaling in neurons | — | 6/79 | 0.002 | 0.438 |
| eNOS signaling | Inhibited (−1.9) | 8/142 | 0.003 | 0.438 | |
| Leukocyte extravasation signaling | Inhibited (−0.7) | 9/198 | 0.006 | 0.443 | |
| IL-4 signaling | — | 5/76 | 0.009 | 0.443 | |
| CCR3 signaling in eosinophils | — | 6/117 | 0.014 | 0.443 | |
| FAK signaling | — | 5/87 | 0.015 | 0.443 | |
| l-dopachrome biosynthesis | — | 1/1 | 0.017 | 0.443 | |
| RhoA signaling | Inhibited (−2.2) | 6/122 | 0.017 | 0.443 | |
| Amyotrophic lateral sclerosis signaling | — | 5/98 | 0.025 | 0.443 | |
| IL-12 signaling and production in macrophages | — | 6/135 | 0.026 | 0.443 | |
| FTC/HCC vs NT | Inhibition of matrix metalloproteases | — | 6/39 | 0.014 | 0.946 |
| Leukocyte extravasation signaling | Inhibited (−1.4) | 18/198 | 0.015 | 0.946 | |
| eNOS Signaling | Inhibited (−1.7) | 14/142 | 0.016 | 0.946 | |
| Tec kinase signaling | Inhibited (−1.9) | 15/158 | 0.017 | 0.946 | |
| HGF signaling | Inhibited (−2.1) | 11/105 | 0.020 | 0.946 | |
| Reelin signaling in neurons | — | 9/79 | 0.021 | 0.946 | |
| FAK signaling | — | 9/87 | 0.036 | 0.946 | |
| Fatty acid α-oxidation | — | 3/16 | 0.047 | 0.946 | |
| VDR/RXR activation | Activated (0.4) | 8/78 | 0.049 | 0.946 | |
| Factors promoting cardiogenesis in vertebrates | — | 9/92 | 0.049 | 0.946 | |
| PTC vs NT | TREM1 signaling | Activated (2.8) | 8/74 | <0.001 | 0.044 |
| IL-10 signaling | — | 7/68 | <0.001 | 0.079 | |
| RhoGDI signaling | Inhibited (−2.3) | 10/173 | 0.003 | 0.192 | |
| Signaling by Rho family GTPases | Activated (2.1) | 12/234 | 0.003 | 0.192 | |
| The visual cycle | — | 3/15 | 0.003 | 0.192 | |
| LXR/RXR activation | Inhibited (−2.1) | 8/121 | 0.003 | 0.192 | |
| VDR/RXR activation | Activated (2.2) | 6/78 | 0.005 | 0.232 | |
| LPS/IL-1 mediated inhibition of RXR function | Activated (1.0) | 11/219 | 0.005 | 0.232 | |
| Integrin signaling | Activated (3.0) | 10/201 | 0.008 | 0.301 | |
| Role of JAK1 and JAK3 in γc cytokine signaling | — | 5/63 | 0.009 | 0.301 | |
| PDTC/ATC vs NT | Agranulocyte adhesion and diapedesis | — | 58/189 | <0.001 | 0.001 |
| Atherosclerosis signaling | — | 41/124 | <0.001 | 0.002 | |
| LXR/RXR activation | Inhibited (−1.0) | 39/121 | <0.001 | 0.004 | |
| Transcriptional regulatory network in embryonic stem cells | — | 18/40 | <0.001 | 0.004 | |
| FXR/RXR activation | — | 39/127 | <0.001 | 0.009 | |
| Granulocyte adhesion and diapedesis | — | 50/177 | <0.001 | 0.009 | |
| GABA receptor signaling | — | 23/67 | <0.001 | 0.031 | |
| Estrogen biosynthesis | — | 15/37 | <0.001 | 0.033 | |
| Gαi signaling | Activated (2.8) | 35/120 | <0.001 | 0.033 | |
| Gαs signaling | Activated (1.0) | 32/109 | <0.001 | 0.045 |