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Percentage injected dose per gram (% ID/g) (A) of Pt in tissues after intraperitoneal administration of NCP-Carbo/GMP in CT26 tumor bearing mice at time points 5 min and 1, 3, 5, 8, 24, and 48 h. Data are mean ± SD (n = 3). Average observed and predicted time-dependent Pt (B) and GMP (C) distributions in blood after administration of NCP-Carbo/GMP (n = 3). A one-compartment model was used in determining the Pt and GMP distribution in blood.
