Table 1.
Score | Signs of toxicity | Classification of toxicity |
---|---|---|
0 | No abnormal gross behavior | Mild |
1 | Facial twitches, pawing at whiskers and mouth, chewing | |
2 | Head tremor and/or nodding, short periods of immobility | Moderate |
3 | Forelimb clonus | |
4 | Rearing with no loss of balance, strong grinding, gnashing or bruxism | Severe |
5 | Rearing with loss of balance, frank convulsions |
The severity of the soman-induced acute toxicity was classified as described in Aracava et al. (2009).