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. 2017 Nov 2;8:1462. doi: 10.3389/fimmu.2017.01462

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Copyright © 2017 Vacca, Böhme, Zambetti, Khameneh, Paleja, Laudisi, Ho, Neo, Leong, Marzuki, Lee, Poidinger, Santambrogio, Tsenova, Zolezzi, De Libero, Singhal and Mortellaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nlrp10 deficiency is associated with increased susceptibility to Mtb infection. (A) Bacterial load was measured in lung from Nlrp10^−/− and WT mice 35 days after Mtb infection. Percentage of CD11b⁺Ly6G⁺ neutrophils (B) and CD11b⁺Ly6C⁺ inflammatory monocytes (C) was determined by flow cytometry in lung cellular suspensions obtained from Nlrp10^−/− and WT mice 7 days after Mtb infection. Frequency and absolute cell numbers are represented as mean ± SE. (D) Representative lung sections of Nlrp10^−/− and WT mice infected with Mtb for 30 days. Magnifications 4×, 40× (H&E), and 80× (AF). *p < 0.05; **p < 0.01; ***p < 0.001. Abbreviations: CFUs, colony-forming units; WT, wild-type.