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Schematic summary of baicalin-driven regulation of autophagy and inflammation during Mtb infection. Baicalin inhibits the phosphorylation of Akt, thus inducing the activation of autophagy through PI3K/Akt/mTOR signaling pathways leading to bactericidal and inflammasome-inhibitory effect. Furthermore, baicalin inhibits the PI3K/Akt/NF-κB pathway contributing to the inhibitory effect on NLRP3 inflammasome activation.
