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. 2017 Nov 2;8:2142. doi: 10.3389/fmicb.2017.02142

Figure 2.

Figure 2

Baicalin can promote the activation of autophagy in Mtb-infected macrophages. (A) Western blot analysis of LC3 I/II and p62 expression in Mtb-infected Raw264.7 cells after treatment with different concentrations of baicalin (0, 12.5, 25, 50, 100 μM) or rapamycin (1 μg/ml) for 12 h. The right bar graphs show the statistical results for the relative quantitative expression of LC3 II and p62. (B) Western blot analysis of LC3 I/II and p62 expression in Mtb-infected Raw264.7 cells. After different times of Mtb infection (0, 4, 12, 24 h), cells were treatment with or without baicalin (100 μM). The right bar graphs showed the statistical results for the relative quantitative expression of LC3 II and p62. (C) Western blot analysis of LC3 I/II and p62 expression in Mtb-infected Raw264.7 cells after treatment with baicalin (100 μM) or CQ (10, 20 μM) for 12 h. The right bar graphs showed the statistical results for the relative quantitative expression of LC3 II and p62 expression. Data are shown with the means ± SD of at least three independent experiments. *p < 0.05.