Table 5.

Proteases involved in digestion of human milk proteins as predicted by enzyme predictor.

Enzyme		N-terminal cleavage count	C-terminal cleavage count	Total cleavage	Unique cleavage	No. of expected cleavages within the peptide	Number of proteins cleaved	Odds ratio
Plasmin	Foremilk	144.0 ± 4.6	194.0 ± 0.9	338.0 ± 5.1	0.0 ± 0.0	564.00 ± 13.63	19.50 ± 0.34	3.6 ± 0.1
	Hindmilk	161.0 ± 4.6	212.5 ± 0.9*	373.5 ± 5.1*	0.0 ± 0.0	682.50 ± 13.63*	19.75 ± 0.34	3.3 ± 0.1
Elastase	Foremilk	54.3 ± 1.6	52.5 ± 3.3	106.8 ± 2.7	0.0 ± 0.0	633.00 ± 18.63	11.50 ± 0.44	0.9 ± 0.0
	Hindmilk	74.8 ± 1.6*	55.3 ± 3.3	130.0 ± 2.7*	0.0 ± 0.0	801.00 ± 18.63*	14.25 ± 0.4*	0.9 ± 0.0
Thrombin	Foremilk	0.2 ± 0.2	0.0 ± 0.0	0.3 ± 0.2	0.3 ± 0.2	0.3 ± 0.2	0.3 ± 0.2	1.3 ± 2.9
	Hindmilk	0.5 ± 0.2	0.0 ± 0.0	0.5 ± 0.2	0.5 ± 0.2	0.5 ± 0.2	0.5 ± 0.2	8.1 ± 2.9

Results are shown as least square mean ± SE, n = 4. Asterisks (*) indicate significant difference between foremilk and hindmilk (P < 0.05).