Table 2.
Summary of meta-analysis of association between small ubiquitin-like modifier 4 (SUMO4) gene M55V polymorphism and type 2 diabetes mellitus (T2DM).
| Genetic model | Pooled OR (95% CI) | Z value | P-value | Study number | T2DM size | control size | |
|---|---|---|---|---|---|---|---|
| Allelic genetic model | 1.18 (1.10–1.28) | 4.31 | 1.63 × 10−5* | 10 | 3,223 | 3,600 | 0.34 (11.0%) |
| Chinese subgroup | 1.24 (1.12–1.38) | 4.10 | 4.13 × 10−5* | 7 | 1,944 | 2,247 | 0.57 (0%) |
| Japanese subgroup | 1.10 (0.98–1.24) | 1.65 | 0.10 | 2 | 1,229 | 1,303 | 0.09 (65.0%) |
| Iranian subgroup | 1.44 (0.82–2.51) | 1.27 | 0.20 | 1 | 50 | 50 | NA |
| Recessive genetic model | 1.59 (1.14–2.23) | 2.73 | 0.006* | 10 | 3,223 | 3,600 | 0.007* (59.0%) |
| Chinese subgroup | 1.71 (1.02–2.86) | 2.03 | 0. 04* | 7 | 1,944 | 2,247 | 0.005* (65.0%) |
| Japanese subgroup | 1.19 (0.92–1.56) | 1.32 | 0.19 | 2 | 1,229 | 1,303 | 0.75 (0%) |
| Iranian subgroup | 2.79 (1.05–7.40) | 2.05 | 0.04* | 1 | 50 | 50 | NA |
| Dominant genetic model | 0.815 (0.737–0.901) | 3.98 | 6.89 × 10−5* | 10 | 3,223 | 3,600 | 0.211 (24.7%) |
| Chinese subgroup | 0.768 (0.673–0.877) | 3.89 | 0.0001* | 7 | 1,944 | 2,247 | 0.417 (1.7%) |
| Japanese subgroup | 0.888 (0.760–1.039) | 1.48 | 0.138 | 2 | 1,229 | 1,303 | 0.043* (75.7%) |
| Iranian subgroup | 0.712 (0.279–1.818) | 0.71 | 0.477 | 1 | 50 | 50 | NA |
| Homozygous genetic model | 1.415 (1.170–1.710) | 3.58 | 0.0003* | 10 | 3,223 | 3,600 | 0.103 (37.1%) |
| Chinese subgroup | 1.580 (1.205–2.071) | 3.31 | 0.001* | 7 | 1,944 | 2,247 | 0.081 (44.6%) |
| Japanese subgroup | 1.236 (0.939–1.627) | 1.51 | 0.131 | 2 | 1,229 | 1,303 | 0.384 (0%) |
| Iranian subgroup | 1.950 (0.648–5.867) | 1.19 | 0.235 | 1 | 50 | 50 | NA |
| Heterozygous genetic model | 1.191 (1.072–1.323) | 3.26 | 0.001* | 10 | 3,223 | 3,600 | 0.072 (41.5%) |
| Chinese subgroup | 1.257 (1.095–1.443) | 3.26 | 0.001* | 7 | 1,944 | 2,247 | 0.031* (66.2%) |
| Japanese subgroup | 1.104 (0.937–1.301) | 1.18 | 0.237 | 2 | 1,229 | 1,303 | 0.043* (75.6%) |
| Iranian subgroup | 1.144 (0.419–3.122) | 0.26 | 0.793 | 1 | 50 | 50 | NA |
| Additive genetic model | 1.184 (1.097–1.279) | 4.31 | 1.63 × 10−5* | 10 | 3,223 | 3,600 | 0.342 (10.7%) |
| Chinese subgroup | 1.241 (1.119–1.377) | 4.10 | 4.13 × 10−5* | 7 | 1,944 | 2,247 | 0.570 (0%) |
| Japanese subgroup | 1.104 (0.981–1.243) | 1.65 | 0.099 | 2 | 1,229 | 1,303 | 0.092 (64.7%) |
| Iranian subgroup | 1.437 (0.823–2.511) | 1.27 | 0.203 | 1 | 50 | 50 | NA |
*P ≤ 0.05.
CI, confidence interval; OR, odds ratio; T2DM size, the total number of T2DM cases; control size, the total number of control group; allelic genetic model, V allele distribution frequency; recessive genetic model, VV vs. MM + MV; dominant genetic model, MM vs. MV + VV; homozygous genetic model, VV vs. MM; heterozygous genetic model, MV vs. MM; additive genetic model, V vs. M.