Figure 2.

NamiRNAs and enhancers are essential to regulate gene expression in controlling cell fate

We propose a NamiRNA–enhancer–cell fate decision network to demonstrate the interactions between the enhancers and NamiRNAs in cell identity determination. A. Under normal conditions, NamiRNAs interact with enhancers to activate the expression of genes related to cell identity, leading to normal cell differentiation. B. Mutations in NamiRNAs may result in the silence or dysfunction of the cell identity-related genes, thus leading normal cells to death or an abnormal state. C. Similarly, mutations in enhancer regions may also contribute to the death or change into an abnormal state for the normal cells.