Table 1. Regulators of wound healing and inflammation found in dHACM (17,22).
| Regulators of wound healing and inflammation found in dHACM |
| Regulators of soft tissue healing in dHACM |
| Cytokines |
| Angiogenin (Ang) |
| Angiopoietin-2 (ANG-2) |
| Basic fibroblast growth factor (bFGF) |
| Beta nerve growth factor (β-NGF) |
| Bone morphogenetic protein 5 (BMP-5) |
| Brain-derived neurotrophic factor (BDNF) |
| Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) |
| Epidermal growth factor (EGF) |
| Fibroblast growth factor 4 (FGF-4) |
| Growth hormone (GH) |
| Heparin binding egf-like growth factor (HB-EGF) |
| Hepatocyte growth factor (HGF) |
| Insulin-like growth factor 1 (IGF-I) |
| Insulin-like growth factor binding protein 1 (IGFBP-1) |
| Insulin-like growth factor binding protein 2 (IGFBP-2) |
| Insulin-like growth factor binding protein 3 (IGFBP-3) |
| Insulin-like growth factor binding protein 4 (IGFBP-4) |
| Insulin-like growth factor binding protein 6 (IGFBP-6) |
| Keratinocyte growth factor (KGF/FGF-7) |
| Placental growth factor (PlGF) |
| Platelet-derived growth factor AA (PDGF-AA) |
| Platelet-derived growth factor BB (PDGF-BB) |
| Transforming growth factor alpha (TGF-α) |
| Transforming growth factor beta 1 (TGF-β1) |
| Vascular endothelial growth factor (VEGF) |
| Vascular endothelial growth factor D (VEGF-D) |
| Matrix metalloproteinases |
| Matrix metalloproteinase 1 (MMP-1) |
| Matrix metalloproteinase 2 (MMP-2) |
| Matrix metalloproteinase 3 (MMP-3) |
| Matrix metalloproteinase 8 (MMP-8) |
| Matrix metalloproteinase 9 (MMP-9) |
| Matrix metalloproteinase 10 (MMP-10) |
| Matrix metalloproteinase 13 (MMP-13) |
| Protease inhibitors |
| Alpha 1 antitrypsin (α1AT) |
| Alpha 2 macroglobulin (α2M) |
| Tissue inhibitor of metalloproteinase 1 (TIMP-1) |
| Tissue inhibitor of metalloproteinase 2 (TIMP-2) |
| Tissue inhibitor of metalloproteinase 4 (TIMP-4) |
| Regulators of inflammation in dHACM |
| Cytokines |
| Granulocyte colony-stimulating factor (GCSF) |
| Granulocyte macrophage colony-stimulating factor (GM-CSF) |
| Growth differentiation factor 15 (GDF-15) |
| Interferon gamma (IFNγ) |
| Interleukin 1 alpha (IL-1α) |
| Interleukin 1 beta (IL-1β) |
| Interleukin 1 receptor antagonist (IL-1RA) |
| Interleukin 4 (IL-4) |
| Interleukin 5 (IL-5) |
| Interleukin 6 (IL-6) |
| Interleukin 7 (IL-7) |
| Interleukin 10 (IL-10) |
| Interleukin 12 p40 (IL-12p40) |
| Interleukin 12 p70 (IL-12p70) |
| Interleukin 15 (IL-15) |
| Interleukin 17 (IL-17) |
| Macrophage colony-stimulating factor (MCSF) |
| Osteoprotegerin (OPG) |
| Prostaglandin E2 (PGE2) |
| Chemokines |
| B lymphocyte chemoattractant (BLC/CXCL13) |
| Chemokine ligand 1 (I-309/CCL1) |
| Eotaxin 2 |
| Interleukin 8 (IL-8) |
| Interleukin 16 (IL-16) |
| Macrophage inflammatory protein 1 alpha (MIP-1α/CCL3) |
| Macrophage inflammatory protein 1 beta (MIP-β1/CCL4) |
| Macrophage inflammatory protein 1 delta (MIP-1δ/MIP-5/CCL15) |
| Monocyte chemotactic protein 1 (MCP-1/CCL2) |
| Monokine induced by gamma interferon (MIG/CXCL9) |
| Regulated on activation, normal t-cell expressed and secreted (RANTES/CCL5) |
dHACM, dehydrated human amnion/chorion membrane.