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. 2017 Nov 6;8:1333. doi: 10.1038/s41467-017-01080-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Dysregulated GG-NER assembly upon ASH1L depletion. a Retention of XPC protein in CPD spots of ASH1L-depleted cells. Transfections with siRNA occurred 48 h before UV radiation (100 J m^–2) through 5-µm filter pores. Immunofluorescence was assessed at the indicated times after treatment. Quantifications show the percentage of CPD-positive cells containing visible protein spots, and ratios of fluorescence intensity of each protein spot divided by the nuclear background (n = 3 with at least 100 cells in each experiment). The intensity ratio seen with siNC controls is set to 100%; error bars show s.e.m. (one-sample t-test). Scale bar = 15 µm. b Impaired relocation of XPD to the CPD spots of ASH1L-depleted cells. Quantifications were based on at least 100 cells per experiment (n = 3, two-tailed t-test).