Table 1.

Comparison of different electrochemical sensors for determination of 8-OHdG.

Working electrode/Substrate	Working electrode/Modification	Detection technique	Range of linear concentration dependence	Type of Sensor	Real application	Reference
2 electrode system/CNT conductive paper	—	Chrono-amperometric (and colorimetric)	0–530 nM	Immuno-sensor	Urine samples	37
3 electrode system/GCE electrode	SWCNTs- Nafion dispersion	DPV	0.03–1.25 mM		Urine samples	40
			1.25–8.75 mM
3 electrode system/GCE electrode	Graphene- Nafion film	LSV	0.07–3.64 mM		Urine samples	39
			3.64–16.24 mM
			16.24–33.04 mM
3 electrode system/GCE electrode	MWCNT film	LSV	80–5000 nM		Urine samples	60
3 electrode system/GCE electrode	Poly(3-methyl thiophene)	CV	0.700–35.0 mM		Urine samples	24
			35.0–70.0mM
3 electrode system/GCE electrode	Poly(indole-5-carboxylic acid) and chitosan	DPV	0.35–35305 nM	Immuno-sensor	Urine samples	59
3 electrode system/Pt electrode	Carbon quantum dot coated with Au/SiO2 core-shell nanoparticles	ECL	0.71–706 nM	Immuno-sensor	Milk samples	14
3 electrode system/Au electrode	Phenol polymer	EIS	0.35–353 pM	MIP	Urine samples	17
3 electrode system/GCE electrode	Sulfur-doped graphene	DPV	0.002–20 mM		Urine samples	41
3 electrode system/GCE electrode	DNA functionalized graphene nanosheets	CV	0.0056–1.155 mM		Urine samples	38
			1.155–11.655 mM
			11.655–36.155 mM

Au: gold; CNT: carbon nanotube; CV: cyclic voltammetry; DPV: differential pulse voltammetry; ECL: electrochemiluminescence; EIS: electrochemical impedance spectroscopy; GCE: glass carbon electrode; HPLC-ECD: High Performance Liquid Chromatography with Electrochemical Detection; LSV: linear sweep voltammetry; MIP: molecularly imprinting polymer; MWCNT: multi walled carbon nanotubes; PAMAM: poly(amidoamine); Pt: platinum; SAM: self-assembled monolayers; SWCNTs: single walled carbon nanotubes.