Table 4.

Inhibition of GlnA by L-Methionine Sulfoximine sensitizes S. pneumoniae to PEN.

Condition	MIC of PEN (µg/mL)a,b
	R6	CCRI-8970	CCRI-21487	CCRI-1397	CCRI-1414	CCRI-1983
CAMHBc	0.03	0.015	0.03	1	2	8
CAMHB + MSOd	0.008	0.008	0.015	0.5	1	2
CAMHB + MSO + Glne	0.03	0.015	0.03	1	2	4

^aMIC of PEN: Minimum Inhibitory Concentration of penicillin.

^bAverage of three biological replicates.

^cCAMHB: Cation Adjusted Muller Hinton Broth.

^dMSO: L-Methionine Sulfoximine added at 0.5 mM.

^eGln: glutamine added at 12 mM.