Table 7.
Initial uptake rates of FMDP-oligopeptides and model alanyl oligopeptides by C. albicans wild type cells and oligopeptide transporters-deficient mutants.
Strain | SC 5314 | opt1Δ | opt2Δ opt3Δ | opt4Δ | opt5Δ | opt1–opt5Δ | ptr2Δ ptr22Δ | opt1–opt5Δ ptr2Δ ptr22Δ | |
---|---|---|---|---|---|---|---|---|---|
Peptide | Uptake rate ± SD [nmol min-1 (mg dry weight)-1] | ||||||||
F2 | 4.83 ± 0.11 | 4.75 ± 0.09 | 4.80 ± 0.15 | 4.86 ± 0.14 | 4.78 ± 0.11 | 4.05 ± 0.18 | <0.1 | <0.1 | |
F3 | 4.32 ± 0.14 | 4.08 ± 0.14 | 3.23 ± 0.19 | 4.12 ± 0.15 | 4.19 ± 0.16 | 2.98 ± 0.18 | 0.11 ± 0.04 | <0.1 | |
P5 | 2.66 ± 0.19 | 2.01 ± 0.16 | 0.52 ± 0.08 | 1.95 ± 0.13 | 1.82 ± 0.11 | 0.39 ± 0.07 | 2.56 ± 0.18 | 0.15 ± 0.04 | |
F6 | 3.12 ± 0.20 | 2.08 ± 0.15 | 0.56 ± 0.09 | 2.99 ± 0.11 | 2.03 ± 0.15 | 0.22 ± 0.04 | 3.00 ± 0.25 | 0.18 ± 0.03 | |
P6 | 2.22 ± 0.11 | 1.85 ± 0.15 | 0.40 ± 0.09 | 2.11 ± 0.16 | 1.99 ± 0.10 | 0.22 ± 0.07 | 2.46 ± 0.19 | 0.12 ± 0.03 | |
F7 | 2.40 ± 0.16 | 1.70 ± 0.12 | 0.46 ± 0.08 | 1.85 ± 0.12 | 1.44 ± 0.10 | 0.32 ± 0.07 | 2.22 ± 0.16 | 0.23 ± 0.02 | |
P10 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | |
F11 | 2.25 ± 0.15 | 1.64 ± 0.11 | 0.22 ± 0.03 | 1.77 ± 0.18 | 1.92 ± 0.18 | 0.33 ± 0.04 | 2.28 ± 0.15 | 0.18 ± 0.02 | |
(Ala)2 | 5.12 ± 0.32 | 4.50 ± 0.36 | 3.96 ± 0.29 | 4.83 ± 0.31 | 5.00 ± 0.38 | 5.88 ± 0.40 | <0.1 | <0.1 | |
(Ala)3 | 5.62 ± 0.33 | 4.89 ± 0.28 | 4.16 ± 0.22 | 3.22 ± 0.27 | 3.61 ± 0.30 | 4.99 ± 0.36 | <0.1 | <0.1 | |
(Ala)4 | 3.75 ± 0.19 | 0.79 ± 0.09 | 1.93 ± 0.15 | 1.72 ± 0.11 | 1.55 ± 0.11 | 0.12 ± 0.02 | 2.72 ± 0.16 | <0.1 |