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. 2017 Nov 7;11:353. doi: 10.3389/fncel.2017.00353

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Copyright © 2017 Hou and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deletion of GluA3 and GluA4 in thalamic neurons has no effect on intrinsic excitability. (A) EPSCs recorded at –70 and +40 mV from a WT (traces in black on the left) and a Gria3/Gria4 double mutant neuron (traces in red on the right) recorded at P14. EPSCs were evoked by stimuli applied to the medial lemniscus as shown in Supplementary Figure S2A. Both neurons showed all-or-none responses. (B) Firing patterns of a WT (traces in black) and a Gria3/Gria4 double mutant neuron (traces in red) recorded at P15. (C) Rheobase (NS, p = 0.60, Wilcoxon test), (D) Slope of F-I curve (NS, p = 0.63, Wilcoxon test), (E) Input resistance (NS, p = 0.65, Wilcoxon test), and (F) Cell capacitance (NS, p = 0.83, Wilcoxon test) of WT (n = 21 cells from 5 mice) and Gria3/Gria4 double mutant neurons (Gria3/4 DKO, n = 23 cells from 3 mice) recorded at P14-16.