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. 2017 Nov 6;7:14508. doi: 10.1038/s41598-017-15155-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clonal analyses of mutations. (A) Each row (horizontal line) represents an individual SNV identified in MSC1. The two heatmaps show the passage at which the corresponding mutations were identified (“Discovery”; left) and the MAF or mutation allele frequencies across the passages (“MAF”; right), respectively. A colored bar (left) indicates the passage assigned to the individual SNVs. If a single mutation was identified at multiple passages, the mutation was assigned to the earliest passage. Mutations of P1 (green), P3 (blue), P5 (yellow), P7 (orange), and P9 (red) are distinguished with respective colors. (B) The mutations identified in MSC2 are similarly shown. (C) Mean of MAFs are plotted for five mutation classes (P1–P9 with respective colors) across five passages of MSC1. Error bars represent the standard error. Except for the P9 mutations (red) whose MAF abruptly increased at P9, P1-P7 mutations show a fluctuation of MAFs across the passages. (D) Similarly shown for the MAF of five mutation classes (mean values with standard error) of MSC2. (E and F) Mean of simulated values of the PDT are plotted for five mutation classes of MSC1 (E) and MSC2 (F).