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. 2017 Nov 6;7:14514. doi: 10.1038/s41598-017-15108-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mucosal absorption-enhancing effect of thiostrepton. (a) Rat jejunum was treated with vehicle alone or with 0.1 or 1 mM thiostrepton and 1 mg 4-kDa FITC-labelled dextran (FD-4). Time-course changes in plasma FD-4 concentration were monitored, and the area under the time–concentration curve between 0 and 6 h (AUC_{0–6 h}) was calculated (b). Data are means ± SD (n = 4). *P < 0.05 vs vehicle-treated group, as determined by using Dunnett’s test. (c) Histological analysis of representative thiostrepton-treated rat jejunum. After 6 h of treatment with vehicle or thiostrepton (0.1 or 1 mM), the jejunum was fixed and stained with haematoxylin and eosin.