Table 3. Statistical association of cytoplasmic H score expression of ARHGAP18 and the expression of other biomarkers.
|
ARHGAP18 cytoplasmic expression |
Significance |
|||
|---|---|---|---|---|
| Parameter | Low no. (%) | High no. (%) | χ2 | P-value |
|
ER | ||||
| Negative | 227 (83.8) | 44 (16.2) | 0.955 | 0.328 |
| Positive | 552 (81.1) | 129 (18.9) | ||
|
PR | ||||
| Negative | 343 (84.3) | 64 (15.7) | 2.962 | 0.085 |
| Positive | 417 (79.9) | 105 (20.1) | ||
|
HER2 | ||||
| Negative | 636 (80.9) | 150 (19.1) | 5.391 | 0.019 |
| Positive | 117 (89.3) | 14 (10.7) | ||
|
Molecular subtypes | ||||
| Luminal | 492 (80.1) | 122 (19.9) | ||
| HER2+ | 117 (89.3) | 14 (10.7) | 6.719 | 0.035 |
| Triple negative | 157 (84.0) | 30 (16.0) | ||
|
p53 | ||||
| Negative | 528 (82.2) | 114 (17.8) | 0.081 | 0.776 |
| Positive | 224 (81.5) | 51 (18.5) | ||
|
Ki67 | ||||
| Negative | 179 (82.1) | 39 (17.9) | 0.004 | 0.951 |
| Positive | 435 (81.9) | 96 (18.1) | ||
|
E-Cadherin | ||||
| Negative | 284 (86.1) | 46 (13.9) | 5.223 | 0.023 |
| Positive | 448 (80.0) | 112 (20.0) | ||
|
N-Cadherin | ||||
| Negative | 147 (78.6) | 40 (21.4) | 5.752 | 0.019 |
| Positive | 440(86.1) | 71 (13.9) | ||
|
TGF-β1 | ||||
| Negative | 274 (79.7) | 70 (20.3) | 1.465 | 0.262 |
| Positive | 246 (83.4) | 49 (16.6) | ||
|
PIK3CA | ||||
| Negative | 129 (79.1) | 34 (20.9) | ||
| Positive | 471 (83.1) | 96 (16.9) | 1.334 | 0.247 |
|
CTEN | ||||
| Negative | 31 (79.5) | 8 (20.5) | 0.363 | 0.514 |
| Positive | 575 (83.2) | 116 (16.8) | ||
Abbreviations: CTEN=C-terminal tensin-like; ER=oestrogen receptor; HER2=human epidermal growth factor receptor 2; PR=progesterone receptors; TGF-β1= Transforming Growth Factor β1.