Table 5. Association of nuclear ARHGAP18 expression and the expression of other biomarkers.
|
ARHGAP18 nuclear expression |
Significance |
|||
|---|---|---|---|---|
| Parameter | Low expression no. (%) | High expression no. (%) | χ2 | P-value |
|
ER | ||||
| Negative | 248 (91.5) | 23 (8.5) | 3.702 | 0.054 |
| Positive | 593 (87.1) | 88 (12.9) | ||
|
PR | ||||
| Negative | 369 (90.7) | 38 (9.3) | 3.381 | 0.066 |
| Positive | 453 (86.8) | 69 (13.2) | ||
|
HER2 | ||||
| Negative | 683 (86.9) | 103 (13.1) | 11.433 | 0.003 |
| Positive | 127 (96.9) | 4 (3.1) | ||
|
Molecular subtypes | ||||
| Luminal | 528 (86.0) | 86 (14.0) | 13.522 | 0.001 |
| HER2+ | 127 (96.9) | 4 (3.1) | ||
| Triple negative | 169 (90.4) | 18 (9.6) | ||
|
p53 | ||||
| Negative | 567 (88.3) | 75 (11.7) | 0.032 | 0.859 |
| Positive | 244 (88.7) | 31 (11.3) | ||
|
Ki67 | ||||
| Low | 179 (82.1) | 39 (17.9) | 10.599 | 0.001 |
| High | 481 (90.6) | 50 (9.4) | ||
|
E-cadherin | ||||
| Negative | 299 (90.6) | 31 (9.4) | 1.784 | 0.182 |
| Positive | 491 (87.7) | 69 (12.3) | ||
|
N-cadherin | ||||
| Negative | 156 (83.4) | 31 (16.6) | 10.828 | 0.002 |
| Positive | 470 (92.0) | 41 (8.0) | ||
|
TGF-β1 | ||||
| Negative | 296 (86.0) | 48 (14.0) | 6.870 | 0.011 |
| Positive | 273(92.5) | 22 (7.5) | ||
|
PIK3CA | ||||
| Negative | 126 (77.3) | 37 (22.7) | 24.932 | <0.001 |
| Positive | 519 (91.5) | 48 (8.5) | ||
|
CTEN | ||||
| Negative | 29 (74.4) | 10 (25.6) | 8.836 | 0.007 |
| Positive | 620 (89.7) | 71 (10.3) | ||
Abbreviations: ER=oestrogen receptor; HER2=human epidermal growth factor receptor 2; PR=progesterone receptors.