Table 2. Subgroup analysis of diagnostic effect.
| Sensitivity | Specificity | Diagnostic odds ratio | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Subgroup | No. studies | No. patients | Value | I2 (%) | P | Value | I2 (%) | P | Value | I2 (%) | P |
|
Race | |||||||||||
| Caucasian | 5 | 651 | 0.91 (0.84–0.96) | 0.0 | 0.513 | 0.87 (0.84–0.89) | 93.5 | 0.000 | 80.01 (27.41–233.57) | 45.7 | 0.118 |
| Others | 7 | 2182 | 0.83 (0.80–0.86) | 66.4 | 0.007 | 0.92 (0.90–0.93) | 72.7 | 0.001 | 59.09 (37.64–92.77) | 38.3 | 0.137 |
|
Number of patients | |||||||||||
| <100 | 5 | 282 | 0.95 (0.85–0.99) | 0.0 | 0.604 | 0.87 (0.82–0.91) | 92.9 | 0.000 | 147.25 (33.91–639.50) | 27.8 | 0.236 |
| ⩾100 | 7 | 2551 | 0.84 (0.80–0.86) | 65.6 | 0.008 | 0.91 (0.90–0.92) | 82.7 | 0.000 | 59.56 (38.97–91.03) | 45.0 | 0.091 |
|
Number of slices detected by PE | |||||||||||
| 2 | 5 | 702 | 0.88 (0.81–0.93) | 28.6 | 0.231 | 0.95 (0.93–0.97) | 35.3 | 0.186 | 138.70 (71.44–269.2) | 0.0 | 0.814 |
| Others | 4 | 1226 | 0.88 (0.84–0.91) | 0.0 | 0.641 | 0.86 (0.83–0.88) | 92.9 | 0.000 | 52.51 (34.95–78.89) | 0.0 | 0.477 |
|
Thicknesses | |||||||||||
| <1 mm | 5 | 491 | 0.85 (0.75–0.92) | 34.3 | 0.193 | 0.86 (0.82–0.89) | 94.5 | 0.000 | 66.07 (20.10–217.27) | 37.4 | 0.172 |
| ⩾1 mm | 3 | 1518 | 0.82 (0.77–0.86) | 83.3 | 0.003 | 0.92 (0.90–0.93) | 55.4 | 0.106 | 28.66 (29.82–115.39) | 66.4 | 0.051 |
|
Interval | |||||||||||
| 200 mm | 5 | 1153 | 0.87 (0.82–0.91) | 24.9 | 0.255 | 0.90 (0.88–0.92) | 86.5 | 0.000 | 71.61 (39.00–131.49) | 23.5 | 0.265 |
| Others | 4 | 803 | 0.89 (0.84–0.93) | 0.0 | 0.614 | 0.91 (0.88–0.93) | 61.3 | 0.052 | 96.78 (39.18–239.06) | 44.0 | 0.148 |
|
Reference method | |||||||||||
| H&E | 4 | 2181 | 0.88 (0.81–0.93) | 45.9 | 0.136 | 0.95 (0.93–0.97) | 0.0 | 0.550 | 131.15 (66.62–258.20) | 0.0 | 0.818 |
| H&E and IHC | 8 | 652 | 0.84 (0.80–0.87) | 63.7 | 0.007 | 0.89 (0.87–0.91) | 90.6 | 0.000 | 50.19 (31.89–78.99) | 33.3 | 0.162 |
|
IHC for CK19 | |||||||||||
| Yes | 3 | 453 | 0.91 (0.84–0.96) | 0.0 | 0.452 | 0.94 (0.91–0.96) | 0.0 | 0.608 | 160.21 (68.80–373.11) | 0.0 | 0.851 |
| No | 9 | 2380 | 0.83 (0.80–0.86) | 60.1 | 0.010 | 0.90 (0.88–0.91) | 90.7 | 0.000 | 53.37 (34.96–81.50) | 31.7 | 0.164 |
|
Excluding TAB | |||||||||||
| Yes | 3 | 453 | 0.91 (0.84–0.96) | 0.0 | 0.452 | 0.94 (0.91–0.96) | 0.0 | 0.608 | 160.21 (68.80–373.11) | 0.0 | 0.851 |
| No | 9 | 2380 | 0.83 (0.80–0.86) | 60.1 | 0.010 | 0.90 (0.88–0.91) | 90.7 | 0.000 | 53.37 (34.96–81.50) | 31.7 | 0.164 |
Abbreviations: CK19=cytokeratin 19; H&E=haematoxylin and eosin staining; IHC=immunohistochemistry; PE=pathological examination; TAB=tissue allocation bias.