Table 2. Summary of plasma miRNA levels at serial time points.
|
Pre-operative |
6 Months |
12 Months |
24 Months |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean* | Median* | (Min, Max) | N | Mean* | Median* | (Min, Max) | N | Mean* | Median* | (Min, Max) | N | Mean* | Median* | (Min, Max) | |
| miR125b | 137 | 10.32 | 10.23 | (8.16, 19.2) | 89 | 10.24 | 10.1 | (8.76, 14.55) | 77 | 10.02 | 9.92 | (8.34, 12.36) | 30 | 10.12 | 9.93 | (9, 15.33) |
| miR141 | 22 | 9.61 | 9.36 | (8.05, 12.84) | 16 | 9.91, | 9.49 | (8.77, 15.04) | 11 | 8.98 | 8.8 | (8.2, 9.89) | 2 | 8.87 | 8.87 | (8.41, 9.33) |
| miR16 | 144 | 15.24 | 15.15 | (12.67, 25.45) | 94 | 15.23 | 15.18 | (9.94, 20.33) | 79 | 15.35 | 15.36 | (11.07, 17.45) | 34 | 15.69 | 15.45 | (14.11, 20.57) |
| miR17-3p | 130 | 8.78 | 8.59 | (6.83, 19.5) | 87 | 8.66 | 8.64 | (7.09, 11.54) | 72 | 8.82 | 8.8 | (7.17, 11.23) | 26 | 9.19 | 8.89 | (7.65, 15.68) |
| miR200b | 58 | 9.35 | 9.21 | (7.15, 19.15) | 48 | 9.38 | 9.39 | (7.79, 12.14) | 42 | 9.27 | 9.21 | (7.63, 11.28) | 21 | 9.02 | 9.07 | (7.24, 12.44) |
| miR203a | 6 | 11.01 | 10.21 | (9.72, 14.27) | 9 | 10 | 9.32 | (8.45, 13.59) | 3 | 11.76 | 10.2 | (9.41, 15.66) | 2 | 10.11 | 10.11 | (8.66, 11.56) |
| miR29a | 133 | 13.93 | 13.79 | (12.21, 23.49) | 87 | 13.91 | 13.92 | (12.55, 16.6) | 76 | 13.99 | 14.01 | (12.53, 16.35) | 31 | 14.14 | 13.83 | (12.67, 19.87) |
| miR31 | 27 | 9.28 | 9.31 | (8.03, 11.58) | 18 | 9.46 | 9.41 | (8.51, 10.91) | 21 | 9.45 | 9.52 | (8.49, 11.53) | 10 | 9.19 | 9.33 | (8.3, 10.33) |
| miR92a | 144 | 15.56 | 15.58 | (8.71, 25.79) | 94 | 15.53 | 15.62 | (10.14, 18.72) | 80 | 15.81 | 15.78 | (14.06, 18.36) | 34 | 15.5 | 15.47 | (8.52, 22.45) |
*miRNA measured in ln (normalised copies).
a
miR-203 was detected in only six patients prior to surgery.